WebThe chemohormonal androgen ablation randomized (CHAARTED) ... patients with high volume disease (HVD), but not those with low volume disease (LVD) [5,6]. Furthermore, the LATITUDE and STAMPEDE trials also proved the upfront use of abiraterone helps improve progression-free and overall survival in mCNPC patients with a high tumor burden ... WebMar 1, 2024 · The CHAARTED and LATITUDE trials demonstrated a survival benefit of docetaxel and abiraterone for hormone-sensitive prostate cancer. In this study, we …
"Discussion on CHAARTED, LATITUDE and STAMPEDE Trials"
WebFirst, they compared how many patients fit the LATITUDE and CHAARTED definitions. While 52.5% met LATITUDE high-risk and 55.4% met CHHARTED “high-volume” defintions, the following table demonstrates that the overlap is not perfect – 18.2% of patients would be classified differently based on the two different criteria! WebFeb 16, 2024 · ARASENS was designed before results were reported for the LATITUDE trial, which showed an OS benefit with androgen receptor pathway inhibitors, 2 and before the long-term survival analysis of the CHAARTED trial. 15 The standard of care for patients with metastatic hormone-sensitive prostate cancer was ADT and docetaxel when … inheritance tax oklahoma laws
The evolving landscape of metastatic hormone-sensitive ... - PubMed
WebFeb 3, 2024 · Background: Recent landmark randomized trials (CHAARTED and LATITUDE studies) have highlighted potent upfront therapy for "high-volume" and "high-risk" metastatic castration-naïve prostate cancer ... WebMay 23, 2024 · Since 2015, two clinical trials, CHAARTED and STAMPEDE arm C, demonstrated that up-front docetaxel plus ADT improves overall survival (OS) in patients with mCSPC. 7,8 Then, in 2024, two clinical trials, LATITUDE and STAMPEDE arm G, showed that up-front abiraterone plus prednisone plus ADT improves OS to a similar … WebUse the word latitude to describe how much freedom you have in making choices. For example, if a teacher gives you latitude in writing your paper, you might get to choose … inheritance tax on 50000