Circeif4g3
WebFeb 2, 2024 · Renal cell carcinoma (RCC) is one of the top ten tumors over the world. RCC is not sensitive to radiotherapy and chemotherapy. Therefore, it is necessary to find new targets for the treatment. CircRNAs are a special type of noncoding RNAs, which play important roles in many types of cancer. In this study, we found circ_000558 was … WebAug 10, 2024 · The formation of a unique back-splice junction (BSJ) differentiates the circRNAs from their linear counterpart. CircRNAs are highly expressed in the central nervous system where many of them are regulated during development 1 – 3, inflammation 4, and also found to function as biomarkers in cancer 5 – 7.
Circeif4g3
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WebJul 2, 2024 · CircEIF4G3 expression was downregulated in patients with GC and predicted poor prognosis. CircEIF4G3 destabilized δ-catenin by forming circEIF4G3/δ … WebCircEIF4G3 destabilizes δ-catenin protein by enhancing TRIM25-mediated ubiquitin degradation and functions as a miRNA sponge to modulate miR-4449/SIK1 axis, which synergistically leads to the ...
Web(A) Cell counting assays for control and circEIF4G3 overexpressing GC cells. (B) The impact of circEIF4G3 overexpression on GC cell proliferation was determined by cell colony formation assay. WebJul 2, 2024 · Mechanistic studies revealed that circEIF4G3 bound to \u03b4-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interacted with miR-4449 to …
WebThe results showed that the expressions of circDDX17, Has_circ_0026344, circVAPA, circNSUN2, circACAP2, circACVRL1 and circEIF4G3 were regulated by 0.8 mmol/L ALO (p<0.001, Figure 3A). Through subsequent screening of target genes, we found that only circNSUN2 and miR-296-5p have targeted binding sites . WebCircEIF4G3 is downregulated in GC. (A) GEO datasets were downloaded for integrated analyses of differentially expressed circRNAs. The common downregulated circRNAs were listed as indicated. (B)...
WebAug 26, 2024 · Circular EIF4G3 (CircEIF4G3; hSA_CIRC_0007991) is downregulated in gastric cancer tissues and is associated with poor clinical prognosis. Overexpression of …
WebAug 22, 2024 · This study found that CircEIF4G3 was down-regulated in gastric cancer patients and predicted poor prognosis. CircEIF4G3 destabilizes δ-catenin by forming a … orchards nursing home warren miWebJul 2, 2024 · Europe PMC is an archive of life sciences journal literature. iptv smarters pro download for windowsWebCircEIF4G3 destabilizes δ-catenin protein and inactivates β-catenin signaling. (A) TRAP experiment and LC-MS/MS analysis. GST protein expression was detected by western blot. δ-catenin protein... iptv smarters pro download androidWebJul 2, 2024 · Overexpression of circEIF4G3 suppressed GC growth and metastasis through the inhibition of \u03b2-catenin signaling, whereas knockdown of circEIF4G3 showed the opposite effects. Mechanistic studies revealed that circEIF4G3 bound to \u03b4-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interacted with miR … iptv smarters pro download appWebJul 2, 2024 · CircEIF4G3 expression was downregulated in patients with GC and predicted poor prognosis. CircEIF4G3 destabilized δ-catenin by forming circEIF4G3/δ … iptv smarters pro download filehorseWebDownload scientific diagram CircEIF4G3 functions as a miR-4449 sponge. (A) RIP assay was applied using Ago2 antibody in GC cells. The relative RNA level of circEIF4G3 was detected by qRT-PCR. orchards of armada villageWebAug 26, 2024 · CircEIF4G3 is expected to be a biomarker and therapeutic target for predicting the prognosis of gastric cancer. By analyzing the Master Gene Expression (GEO) dataset, we identified circRNAs that are differentially expressed in GCs. The researchers explored the biological role of circRNAs in GC through in vitro functional analysis and in … iptv smarters pro download for firestick