WebSep 24, 2024 · Here, we report that G10, a human-specific agonist of stimulator of interferon genes (STING), activates both type I IFN and the canonical NLRP3 inflammasome in a STING-dependent manner in porcine cells. WebSep 10, 2024 · G10 was originally identified as a human STING dependent activator of the IRF3 pathway whose direct action was on a yet unknown factor distinct from human STING . The molecule was non-polar in nature and structurally distinct from DMXAA, a murine …
G10 activity is STING variant dependent. G10 activates the …
WebG10 is a direct activator of human STING. M Banerjee, S Middya, R Shrivastava, S Basu, R Ghosh, DC Pryde, ... PLoS One 15 (9), e0237743, 2024. 13: 2024: Multi-oriented text detection in natural scene images based on the intersection of MSER with the locally binarized image. A Agrahari, R Ghosh. WebSep 24, 2024 · The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells Pigs have anatomical and physiological … diamond live chat
G10 is a direct activator of human STING.
WebJan 8, 2024 · PLOS ONE G10 is a direct activator of human STING September 10, 2024 Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes … WebJan 2, 2024 · Use of G10, STING signaling activator. STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM). IC50 value: 24.57 μM (IC90)Target: VEEV, STINGin vitro: … WebThe cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the mouse, the STING driven innate immune … diamond lite crowns