Irf3 transcription factor

Author: looa

August undefined, 2024

WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses.

Regulation of IRF3 activation in human antiviral ... - ScienceDirect

Web1 day ago · STING recruitment of TBK1 and IRF3 results in IRF3 phosphorylation by TBK1 and IRF3 55 nuclear translocation[18, 19]. Activated STING also activates IKK and the NF-κB family of 56 transcription factors[20], which with IRF3, activate expression of type I IFN and subsequently 57 ISGs. ISGs include an array of anti-HIV restriction factors ... WebMay 27, 2024 · Thereafter, TBK1 in this signalosome phosphorylates C-terminus of interferon regulatory factors 3 (IRF3), which mobilizes IRF3 for dimerization and nuclear translocation, where it functions as transcription factor to induce the expressions of type I interferons (IFN-Is), various cytokines, and subsequently a multitude of IFN-stimulated … can i hyperlink to a folder

IRF3 - an overview ScienceDirect Topics

WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of … WebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB … WebDec 4, 2024 · IRF3 and IRF5 are phosphorylated by protein kinases, which are activated by signalling pathways of pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) that signal via TRIF (TLR3 and TLR4) and MyD88 (e.g. … can i hyperlink a pdf file to a word document

IRF3 Gene - GeneCards IRF3 Protein IRF3 Antibody

Triggering the interferon response: the role of IRF-3 transcription factor

WebIRF3 Transcription Factor Assay Kit (Colorimetric) (ab207210) is a high throughput assay to quantify IRF3 activation in nuclear extracts. This assay combines a quick ELISA format … WebApr 11, 2024 · TLR signaling cascades typically converge on transcription factors such as NFκB, AP-1, and IRF3 that initiate the synthesis of a battery of innate immune effectors involved in antibacterial ... fitzgerald ranch holbrook azWebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and … fitzgerald public schools warren

"WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3. " - Irf3 transcription factor

Irf3 transcription factor

STING-IRF3 pathway links endoplasmic reticulum stress with ... - PNAS

WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … WebAutophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities Autophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities J Biol Chem. 2024 Oct 5;297 (5):101274. doi: 10.1016/j.jbc.2024.101274. Online ahead of print.

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WebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … WebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. …

WebJan 8, 2024 · Transcriptional activation of the IFNβ promoter by IRF3/7 has been extensively studied (9, 10), and proceeds with phosphorylation of IRF3/7 by the kinase TKB1, leading … WebJan 8, 2024 · The mammalian IRF family proteins are structurally related transcription factors consisting of nine members: IRF1, IRF2, IRF3, IRF4 (also called ICSAT [IFN consensus sequence-binding protein for activated T-cells], LSIRF [lymphocyte-specific IRF], PIP [PU.1-interacting protein]), IRF5, IRF6, IRF7, IRF8 (also referred to ICSBP [IFN …

WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is … WebHowever, the mechanisms by which IRF3 causes ALD remain obscure.IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes …

WebThe interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-alpha/beta) gene promoters, as well as the interferon-stimulated response element (ISRE) of some IFN-stimulated genes. IRF-3 was orig …

WebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria. can i hyperlink in excelWebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... fitzgerald ranch plush oregonWebNov 1, 2012 · IFN regulatory factor 3 (IRF3) regulates early type I IFNs and other genes involved in innate immunity. We have previously shown that cells undergoing an endoplasmic reticulum (ER) stress response called the unfolded protein response produce synergistically augmented IFN-β when stimulated with pattern recognition receptor … can i hypnotize myselfWebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW fitzgerald racingWebNov 20, 2024 · Interferon Regulatory Factors (IRFs) are a family of transcription factors that signal downstream of multiple pathways, including Toll-like receptor (TLR), retinoic acid-inducible gene I (RIG-I), melanoma differentiation associated gene 5 (MDA5), and B cell receptor (BCR) signaling pathways to regulate gene expression involved in both innate … fitzgerald rd queensburyWebApr 14, 2003 · The transcription factors interferon regulatory factor 3 (IRF3) and NF-κB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of ... can i hypnotize myself to lose weightWebJun 19, 2012 · Given that IRF3 acts as a transcription activator for promoters of genes encoding type I interferons but not for the Il12b promoter, it will be useful to explore the molecular mechanism by... can i hyphenate my last name after divorce